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Septic shock is a life-threatening condition requiring intense patient monitoring and supportive therapy for organ dysfunction. Release of inflammatory mediators leads to widespread vasodilatation, capillary leak and reduced systemic vascular resistance. After initial fluid resuscitation, vasopressor therapy is required. These agents have their effect by increasing vascular resistance, raising mean arterial pressure and maintaining perfusion of critical body tissues and organ systems.

Source: Myura Nagendran, corresponding Mahiben Maruthappu, Anthony C Gordon, and Kurinchi S Gurusamy
J Intensive Care Soc. 2016 May; 17(2): 136–145.
Published online 2015 Dec 17. doi: 10.1177/1751143715620203
PMCID: PMC5606402
PMID: 28979478