Dependex® is an orally active, long-acting specific opioid antagonist and is used to medically support chronic alcohol withdrawal treatment. The main effect of the treatment with Dependex® appears to be a reduced risk of total relapse after consuming a small amount of alcohol. This gives the patient the opportunity to escape a total crash with loss of control due to decreased stimulation. Naltrexone hydrochloride reduces craving for alcohol during abstinence and after alcohol intake. Reducing craving for alcohol lowers the risk of relapse in abstinent and non-abstinent patients.