Seltene Erkrankungen im Fokus
AOP Health ist ein europäischer Pionier, der sich auf die Entwicklung, das Marketing und den Vertrieb von Arzneimitteln für die Menschen mit seltenen und komplexen Erkrankungen konzentriert.
Why did you found AOP Health?
“When founding AOP Health in 1996 – as AOP Orphan – my aim was to make targeted treatment available to the maximum number of patients with rare diseases. I realized that these patients are frequently left alone in their suffering. As an entrepreneur the complex environment of rare diseases was a great challenge, but also an opportunity to be successful in this niche.”
What role did AOP Health’s sense of entrepreneurial responsibility play in the founding of the company?
“Entrepreneurial responsibility is no additionally imposed obligation for AOP Health, but the attitude that played an indispensable role at the very time the company was founded. AOP Health’s objective to provide effective help for persons with rare diseases originated from this sense of responsibility and has made the company what it is today.“
“I worked for several years in large international pharmaceutical companies and observed that there were some therapy options for rare diseases, but they did not reach the large majority of the patients.”
Fakten & Zahlen
Seit über 20 Jahren widmet sich AOP Health der pharmazeutischen und klinischen Entwicklung sowie der Kommerzialisierung von Arzneimitteln.
Unsere Motivation bei der AOP Health ist es, Patient*innen, die an seltenen Erkrankungen leiden, zu helfen. Dies erreichen wir in der Zusammenarbeit mit den Stakeholdern des deutschen Gesundheitssystems. Kooperationen in der Pharma- und Gesundheitsbranche sind entscheidend um die Lösungen für PatientInnen entwickeln zu können und diese verfügbar zu machen - insbesondere bei der Behandlungen von seltenen und komplexen Erkrankungen.
AOP Health ist in vielen Ländern vertreten, allerdings nimmt Deutschland eine Sonderstellung ein, da das Land eines der ersten Expansionen des Unternehmens gewesen. AOP Health Deutschland begann seine Entwicklung im Jahre 2011 und wurde 2018 in eine juristische Person umgewandelt.
AOP Health Deutschland ist ein Team von 18 Mitarbeiter*innen in den Bereichen Marketing & Vertrieb, Medical, Market Access, Accounting, Controlling, HR und Office Management.
Vision & Mission
Milestones
History of more than 20 years means many significant milestones — in research, social, business spheres and regulatory affairs — that were and are important for AOP Health.
2022 – New brand name: AOP Health
The brand name was changed to AOP Health to reflect the expansion of business activities beyond rare diseases covering all of the Group’s business segments including critical care.
AOP Orphan Group
AOP Orphan took over the Viennese pharmaceutical company Amomed and the Luxembourgish health-tech company SciPharm.
BESREMi® Approval
On Feb 15th EMA approves AOP Orphan’s BESREMi® as firt-line monotherapy in adults for the treatment of Polycytheamia vera (PV) without symptomatic splenomegaly.
Treprostinil and PAH
The paper “Subcutaneous treprostinil for the treatment of severe non-operable chronic thromboembolic pulmonary hypertension (CTREPH): a double-blind, phase 3, randomised controlled trial" was published by R. Sadushi-Kolici R; Jansa P; Kopec G; Torbicki A; Skoro-Sajer N; Campean IA; Halank M; Simkova I; Karlocai K; Steringer-Mascherbauer R; Samarzija M; Salobir B; Klepetko W; Lindner J; Lang IM (Source: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(18)30367-9/fulltext). The authors conclude that sc. Treprostinil significantly improves the cardiovascular situation and performances figure of patients with CTREPH.
Landiolol approval
Landiolol, a new ultra-high selective short acting beta 1 adrenoceptor blocker, developed by AOP in 2 forms (20 mg/2ml concentrate, 300 mg powder) is registered in several European countires for the treatment of non-compensatory sinus tachycardia and tachycardic supraventricular arrhythmias. The drug uses a new AOP Orphan-developed dosing algorithm to facilitate the administration and proves to be superior to Esmolol in its ability to reduce heart rate more than blood pressure.
Pitolisant approval
Pitolisant, also known as tiprolisant, is a potent and selective inverse agonist of the histamine H3 receptor (Ki = 0.16 nM), and was approved for the treatment of narcolepsy in 2016. Pitolisant was developed by Jean-Charles Schwartz, Walter Schunack, and colleagues, after the former discovered the H3 receptor. It was the first H3 receptor inverse agonist to be tested in humans or introduced for clinical use.
Beta-blocker for severe sepsis
The paper “Beta-blocker use in severe sepsis and septic shock: a systematic review.” by Sanfilippo F1, Santonocito C2, Morelli A3, Foex P4 describes the ability of beta blockade to modulate sepsis-induced alterations at the cardiovascular, metabolic, immunologic and coagulation levels.
Start of the PROUD PV Study
The PROUD-PV study is a phase III study to compare the efficacy and safety of the novel ropeginterferon α-2b versus hydroxyurea in both HU-naive and currently treated patients, diagnosed with Polycythemia vera.
Nabilone Approval in Austria
Nabilone is a synthetically produced substance belonging to a group of compounds known as cannabionoids, used for the treatment of CINV.
Tetrabenazine Approval in Central Europe
Tetrabenazine approval for the treatment of Huntington's chorea in 23 European countires till the end of 2011.
UDCA Designation
In 2010 EMA designated UDCA an "orphan medicine" status — a medicine used for the treatment of primary biliary cholangitis.
Renaissance of Interferon (IFNα)
IFNα has been used to treat malignant and viral disorders for more than 25 years.
A few clinical trials starting from 2008 showed that interferon is effective in normalizing blood counts, reducing the mutant JAK2 allele burden and, in some cases, reversing disease progression.
JAK2 Discovery
The Janus Kinase 2 gene (JAK2) was discovered in 2005. It provides instructions to cells for making the JAK2 protein. The test looks for mutations in JAK2 that are associated with bone marrow disorders caused by the production of too many blood cells.
Prostacyclin Analogues Approval
Subcutaneous prostacyclin analogue approved for the treatment of pulmonary arterial hypertension (PAH) in Europe.
European Union Expansion
The European Union (EU) has expanded several times throughout its history via the accession of new member states. The EU expansion towards Eastern and Central Europe and the Western Balkans had a positive influence on the territorial expansion of AOP Orphan as well, creating a basis for providing treatments for rare diseases in all AOP Orphan core markets.
1st Approval of Anagrelide in Europe
First marketing authorization for Anagrelide in Austria for treatment of patients with essential thrombocythemia.
The Orphan Regulation EC no 141/2000
European Parliament adopted Regulation EC No 141/2000 The Orphan Regulation of Dec 16th, 1999. The Regulation lays down the EU procedure for the designation of orphan medicines, defines incentives for the development and placing of designated orphan medicines in the market, and establishes the Committee for Orphan Medicinal Products (COMP).
Foundation of AOP Orphan in Vienna
Dr. Rudolf Widmann established a successful innovative pharmaceutical company focussed on the treatment of rare diseases in 1996 in Vienna, Austria.
Corporate culture
Since its very start AOP Health has borne the corporate responsibility of further life quality improvement for patients with severe, rare and life-threatening diseases. We at AOP Health conduct intensive research for this purpose, believing that developing and providing solutions for patients is the most important part of the AOP Health corporate responsibility. When it comes to wanting the best for the patients, we stand side-by-side with each other as a team, with researchers, physicians, therapists, caregivers and, patient organizations.
AOP Health is keen to keep one of its greatest assets – it is closely networked with the key specialists in all markets and is therefore able to help patients with rare diseases from Austria throughout the world.
From its inception AOP Health's culture is shaped by the entrepreneurial spirit of its founder. We are proud to be a company that encourages employees to come up with new ideas and to show ownership and initiative every day. To help neglected patients with rare diseases is our key motivator. Through close interaction with the scientific community, care givers and partners we aim to provide therapies and help patients beyond just providing drugs.
The future
Thanks to our advancements in the field of therapies, an increasing number of patients survive their disease or are able to live with it for a longer period of time. In the next few decades, personalized medicine, individual treatment opportunities will emerge more and more as the standard in AOP Health’s therapy concepts as well.
Novel technologies such as next-generation sequencing (NGS) will play an equally crucial role as the increasing quantities of big data and conclusions derived from the daily lives of patients also beyond the strictly regulated conditions of clinical trials, e.g. real-world evidence.
Furthermore, the increasing health competence, health literacy of patients and their family members will also determine the future of pharma and health care sector.
Das AOP Health Headquarters Team in Wien deckt alle wesentlichen Aspekte der Produktentwicklung ab, angefangen bei der präklinischen Forschung und Toxikologie über die pharmazeutische und klinische Entwicklung bis hin zu regulatorischen Angelegenheiten, Qualitätsmanagement und Pharmakovigilanz. Erfahren Sie mehr auf der globalen Website auf Englisch
Die Kooperationen sind für AOP Health von zentraler Bedeutung. Diese ermöglichen die Weiterentwicklung des Portfolios für seltene Krankheiten von AOP Health und den Zugang von PatientInnen außerhalb der Kernmärkte des Unternehmens in Europa. Erfahren Sie mehr über die Möglichkeiten der Zusammenarbeit mit AOP Health auf der globalen Website auf Englisch